Spike Protein Antibody (Blood Test) FAQ

What is the Spike Protein Antibody test? 

- A test for antibodies made against the spike protein of the COVID-19 virus.  


What is the difference between the IgG Antibody test and the Spike Protein Antibody test?  

- IgG COVID-19 Antibody (Blood Test): 

- This was the first antibody test developed for COVID-19 – it potentially identifies antibodies created by you in response to an infection in order to fight the COVID-19 virus. It does NOT test for antibodies made in response to COVID-19 vaccination.  

- Spike Protein COVID-19 Antibody (Blood Test): 

- This test potentially identifies antibodies created by you in response to vaccination against the COVID-19 virus. It can also detect antibodies made in response to a COVID-19 infection.


What does the Spike Protein Antibody test detect?  

- The body makes a class of proteins called antibodies which bind to organisms (i.e. COVID-19 virus) in order to fight off infection. Our bodies make multiple different antibodies which bind selectively to various components of the COVID-19 virus. We now have blood tests to detect two of these distinct antibodies, one of which is the Spike Protein antibody.     


How is the test administered?  

- Administered via a blood sample.


What platform do you use for the Spike Protein Antibody testing? 

- Roche e411.


How long after I am vaccinated should I wait to get my Spike Protein Antibody Test?  

- It is not currently recommended that patients have their spike protein antibody levels routinely checked as there are still many details the medical community has not clarified.  One should wait at least 2 weeks after their second dose of the Pfizer or Moderna vaccine or after the single dose of the Johnson & Johnson vaccine if they want to have their antibody levels checked. 


What is the turnaround time for results?  

- Please allow 3-5 days to receive your results. Your results can be viewed via your CityMD Patient Portal account. Once you are in your CityMD Patient Portal Account, please check your “lab reports” or “visit summary” for your results. You will receive a text message or email with a link to our portal.                                       

Is this test covered under the CARES act? Will my insurance be charged? 

-The Spike Protein Antibody test will be covered under the CARES Act. Under the parameters of the CARES Act, all health plans must provide coverage without applying any cost sharing to the patient.